Hai Xu（Professor）

  Name：

Hai Xu

Academic Title：

Professor

Advisor Type：

Supervisor of PhD and MSc students

  Department：

 Biological and Energy Chemical Engineering

Research Interests：

Biological Engineering, Colloid and Interface Chemistry

  E-Mail：

xuh@upc.edu.cn

Group Website

https://www.x-mol.com/groups/jiqian

  Telephone：

0532-86981569

◎Educational Background

1989-1993, China University of Petroleum (East China), Applied Chemistry，BSc

1994-1997, China University of Petroleum (East China), Applied Chemistry，MSc

1998-2002, China University of Petroleum (East China), Chemical Engineering and Technology，PhD

◎Work Experience

1993-present, China University of Petroleum (East China), Teaching assistant/ Lecturer/Associate Professor /Professor

2003-2005, University of Manchester, Postdoctoral Fellow

◎Research Direction

[1] Peptide Design, Self-Assembly and Peptide-Based Biomaterials

[2] Enzymes in Industry and Biomimetic Catalysis

[3] Neutron Reflection and Scattering

◎Research Project

[1] NSFC grant: Rational design of peptide co-assembly for the construction and modulation of sophisticated supramolecular systems

[2] NSFC grant: Study of self-assembled peptide nanostructures and dynamics using small angle neutron scattering

[3] NSFC grant: Design and construction of nano metalloenzymes via peptide self-assembly and their structures and properties

[4] NSFC grant: Enzyme-mediated hydrogelation and biofunctionalization of short peptide self-assemblies and their application to cell culture

◎Representative Papers and Patents

1. Paper (corresponding author in the past five years)

[1] Enzymatically functionalized RGD-gelatin scaffolds that recruit host mesenchymal stem cells in vivo and promote bone regeneration. J. Colloid. Interface Sci. 2022, 612, 377~391.

[2] Ordered packing of β-sheet nanofibrils into nanotubes: multi-hierarchical assembly of designed short peptides. Nano Lett 2021, 21, 10199-10207.

[3] Unexpected role of achiral glycine in determining the suprastructural handedness of peptide nanofibrils. ACS Nano 2021, 15, 10328–10341.

[4] Monolayer wall nanotubes self-assembled from short peptide bolaamphiphiles. J. Colloid. Interface Sci. 2021, 583, 553-562.

[5] Ordered nanofibers fabricated from hierarchical self-assembling processes of designed α-helical peptides. Small 2020, 16, 45, 2003945.

[6] Dual mode of anti-biofilm action of G3 against Streptococcus mutans. ACS Appl. Mater. Interfaces 2020, 12, 27866-27875.

[7] Surfactant-like peptides: From molecular design to controllable self-assembly with applications. Coord. Chem. Rev. 2020, 421, 213418.

[8] Rapid hemostasis resulting from the synergism of self-assembling short peptide and O-carboxymethyl chitosan. ACS Appl. Mater. Interfaces, 2020, 12, 50, 55574-55583.

[9] Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy. ACS Appl. Mater. Interfaces 2019, 11, 16357−16366.

[10] Amino acid conformations control the morphological and chiral features of the self-assembled peptide nanostructures: Young investigators perspective. J. Colloid Interface Sci. 2019, 548, 244–254

[11] Controlling the diameters of nanotubes self-assembled from designed peptide bolaphiles. Small 2018, 14, 1703216.

[12] Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets. Nat. Commun. 2018, 9, 1, 1-11.

[13] Left or right: How does amino acid chirality affect the handedness of nanostructures self-assembled from short amphiphilic peptides? J. Am. Chem. Soc. 2017, 139, 4185–4194.

[14] Peptide Self-Assembled Nanostructures with Distinct Morphologies and Properties Fabricated by Molecular Design. ACS Appl. Mater. Interfaces 2017, 9, 39174-39184.

[15] Rational Design of Short Peptide-Based Hydrogels with MMP‑2 Responsiveness for Controlled Anticancer Peptide Delivery. Biomacromolecules 2017, 18, 3563-3571.

◎Representative Works

[1] Petroleum Composition and Conversion Chemistry, China University of Petroleum Press, 2008

◎Awards and Honors

[1] National Science Fund for Outstanding Young Scholars of Shandong Province

[2] Education Ministry's New Century Excellent Talents Supporting Plan

◎Courses Offered

Undergraduate：《Biochemistry》

Postgraduate：《Biochemistry and Engineering》

◎Student Training

1. Supervise Postgraduate Students

I have supervised more than 30 PhD and MSc students of chemical engineering and bioengineering. Most of them are now employed by petroleum companies, colleges, government agencies and other enterprises. Some of them are studying abroad for PhD degree in US, Australia and Europe after graduation.

2. Admissions Instructions：

PhD students in Chemical Engineering and Technology.

MSc students in Chemical Engineering and Technology, Biotechnology and Engineering.

◎Part-time Academic Job

[1] Member of Peptide Branch Expert Committee of China Biochemical Pharmaceutical Industry Association

[2] Editorial Board Member of Colloids and Surfaces A

[3] Member of Shandong Committee of Biochemistry and Molecular Biology