Cuixia Chen（Professor）

  Name：

Cuixia Chen

Academic Title：

Professor

Advisor Type：

Master tutor

  Department：

Research Interests：

Biomaterials and Biochemistry, Biology   and medicine

  E-Mail：

chencx@upc.edu.cn

  Telephone：

0532-86981561

◎Educational Background

1998-2002,   Bachelor of Science, Department of Biological Sciences, College of Life Sciences,   Liaocheng University

2002-2007,   PhD, Institute of Genetics and Cell Sciences, Northeast Normal University

2014-2015,   Visiting Scholar of China Scholarship Council, University of Manchester

◎Work Experience

2007-2010,   Bioengineering and Technology Center, School of Chemical Engineering,   Lecturer

2010-2016,   Bioengineering and Technology Center, School of Chemical Engineering,   Associate Professor

2016-,   Department of Biology and Energy Chemical Engineering, School of Chemistry   and Chemical Engineering, Professor

◎Research Direction

[1] Study on   the relationship between and the structure and function of peptide   self-assembly nanoparticles.

[2]   Polypeptide biomaterials (antibacterial, anti-tumor and anti-bacterial   biofilm short peptides; Hemostasis, tissue engineering peptide hydrogel,   etc.), bioengineering expression and application in biomedical fields.

[3]   Monitoring, isolation and identification of Marine bacteria in Marine   environment and sulfuric acid reducing bacteria in terrestrial petroleum   environment. Resource assessment of Marine cash crops (e.g., swimming crab).

◎Research Project

[1]   Preparation of self-assembled hydrogels with double enzyme responsive peptide   and its effect on tumor cell behavior, Natural Science Foundation of Shandong   Province, Young Fund, ZR2021MC122, in research.

[2] DNA   analysis of Portunus tricolata in columnar sediments from Shandong Sea, Bohai   Sea, China. Science and Technology Project, HX20210515, in progress.

[3] DNA   analysis of fish eggs, larvae and larvae in Bohai And Shandong waters,   Science and Technology Project, HX20220221, in research.

[4]   Self-assembly research of FNS, Science and Technology project entrusted by   enterprises and Public institutions, in charge, HX20190897, in research.

[5]   Preparation of diatom shells and its application in biomedicine, Science and   Technology, 27R1804040A, in research.

[6] (AABB)   Study on the antitumor and cytoselective mechanism of n-type A-helix   peptides, National Natural Science Foundation of China, 31271497, concluded.

[7] Key Project   for Young Teachers, Principal investigator, 14CX02189A, Conclusion.  

[8] (XXYY)   Design and antibacterial activity of N-type α -helical peptide, Chinese   Journal of Education, 27R1204028A, concluded.

[9]   Self-assembly and antitumor activity of AxK short peptide, Natural Science   Foundation of Shandong Province, Young Fund, ZR2009DQ001, concluded.

[10] Antitumor   activity of AmKn self-assembled peptide, National Natural Science Foundation of   China, 30900765, concluded.

◎Representative Papers and Patents

1. Paper

[1]   Cuixia Chen*,   Jiaxi Chen, Qizhi Yu, Jiangyu Zhang, Xiaoya Niu, Liyun Hao, Liuin Yang,   Yurong Zhao*, Effect of Salts on the Self-Assembly Behavior and Antibacterial   Activity of a Surfactant-Like Peptide, Soft   Matter, 2020, 16, 9758-9768. (   IF 3.758 )

[2] Jiangyu Zhang,   Cuixia Chen*, Jiaxi Chen, Shasha Zhou, Yurong Zhao, Minglu Xu, Hai   Xu*, Dual Mode of Anti-Biofilm Action of G3 against Streptococcus mutans, ACS Appl. Mater. Interfaces2020, 12, 27866−27875. ( IF 8.758 )

[3] Cuixia   Chen*, Gongrang Li, Xuejing   Cui, Jiaxi Chen, Qizhi Yu, Cheng Zong, Yurong Zhao, Minglu Xu, Shasha Zhou,   Hai Xu*, Mechnistic Investigation of a Self-Assembling Peptide against   Escherichia coli, Langmuir, 2020,36（33）9800-9809.   ( IF 3.258 )

[4]Ruirui Hao, Xiaoting Peng, Yan   Zhang, Jiaxi Chen, Tong Wang, Wenxin Wang, Yurong Zhao, Xinglong Fan*, Cuixia Chen*, Hai Xu*，ACS Appl. Mater. Interfaces 2020,   12, 50, 55574–55583 ( IF 8.758 )

[5] Yurong Zhao*, Xingfan Li, Limin Zhang, Dong Wang,   Wenxin Wang, Li Wang, Cuixia Chen*,   Tuning the Self-Assembled Nanostructures of Ultra-Short Bola Peptides via   Side Chain Variations of the Hydrophobic Amino Acids, J. Mol. Liq.，315,113765.   ( IF 6.758 )

[6]   Cuixia Chen,*   Jingxin Wang, Ruirui Hao, Zheng Wang, Zhe Hou, Yurong Zhao, Cheng Zong, and   Hai Xu*, Transglutaminase-Triggered Gelation and Functionalization of   Designed Self-Assembling Peptides for Guiding Cell Migration, ACS Appl. Bio Mater.2018, 162110-2119.

[8]   Cuixia Chen*, Yu   Zhang, Zhe Hou, Xuejing Cui, Yurong Zhao, and Hai Xu*，Rational Design of Short Peptide-Based Hydrogels with   MMP‑2 Responsiveness for Controlled Anticancer Peptide Delivery, Biomacromolecules2017, 18, 3563−3571. （SCI, IF5.8）

[9] Cuixia Chen, Jing Hu, Cheng Yang, Yu Zhang, Fang Wang, Quanmeng Mu,   Fang Pan, Hai Xu and Jian Ren Lu，Amino acid side chains affect the bioactivity of   designed short peptide amphiphiles, J.   Mater. Chem. B, 2016, 4:   2359-2368（SCI, IF4.3）

[10]   Jingkun Bai, Cuixia Chen,   Jingxin Wang, Yu Zhang, Henry Cox, Jing Zhang, Yuming Wang, Jeffrey Penny,   Thomas Waigh, Jian R. Lu, and Hai Xu，Enzymatic Regulation of Self-Assembling Peptide   A9K2 Nanostructures and Hydrogelation with Highly Selective   Antibacterial Activities, ACS Appl. Mater. Interfaces,2016, 8 (24):15093–15102.   （SCI,   IF7.1, co-first author）

[11] Cuixia Chen, Yu Zhang, Rui Fei, Changhai Cao, Meng Wang, Jingxin   Wang, Jingkun Bai, Henry Cox, Thomas Waigh, Jian R. Lu, and Hai Xu,   Hydrogelation of the short self-Assembling peptide I3QGK regulated   by transglutaminase and use for rapid hemostasis, ACS Appl.   Mater. Interfaces, 2016, 8 (28):17833–17841.   （SCI,   IF7.1）

[12] Cuixia Chen, Cheng Yang, Yucan Chen, Fang Wang, Quanmeng Mu, Jing   Zhang, Zongyi Li, Fang Pan, Hai Xu, and Jian Ren Lu，Surface Physical Activity and Hydrophobicity of   Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell   Selectivity,  ACS Appl. Mater. Interfaces,2016,8(40),   26501–26510. （SCI,   IF7.1）

[13] Cuixia Chen,Yucan Chen,Cheng Yang,Ping Zeng,Hai Xu,Fang Pan,and Jian Ren Lu，High Selective Performance of Designed   Antibacterial and Anticancer Peptide Amphiphiles, ACS Appl. Mater. Interfaces2015,   7:17346−17355.   （SCI,   IF7.1）

[14] Cuixia Chen, Jing Hu, Ping Zeng, Yucan Chen, Hai Xu, and Jian R.   Lu，High   Cell Selectivity and Low-Level Antibacterial Resistance of Designed   Amphiphilic Peptide G(IIKK)3I‑NH2, ACS Appl. Mater. Interfaces2014, 6:16529−16536. （SCI, IF7.1）

[15] Cuixia Chen, Jing Hu, Ping Zeng, Fang Pan, Mohammed   Yaseen, Hai Xu ,Jian R. Lu，Molecular mechanisms of anticancer action   and cell selectivity of short a-helical peptides, Biomaterials2014,   35:1552-1561.（SCI, IF8.3）

[16] Cuixia Chen, Yanfeng Gu, Li Deng, Shuyi Han, Xing Sun, Yucan Chen, Jian R. Lu, and Hai Xu，Tuning Gelation Kinetics and Mechanical Rigidity of β‑Hairpin   Peptide Hydrogels via Hydrophobic Amino Acid Substitutions，ACS   Appl. Mater. Interfaces2014,   6:14360−14368. （SCI,   IF7.1）

[17] Hai Xu, Cuixia Chen, Jing Hu, Peng   Zhou, Ping Zeng, Changhai Cao, Jian R Lu, Dual modes of antitumor action of   an amphiphilic peptide A9K, Biomaterials,   2013, 34(11): 2731–2737. （SCI, IF7.1）

[18] Cuixia Chen, Jing Hu, Shengzhong Zhang, Peng Zhou, Xichen Zhao,   Hai Xu、Xiubo Zhao, Mohammed   Yaseen, Jian R Lu, Molecular mechanisms of antibacterial and antitumor   actions of designed surfactant-like peptid, Biomaterials, 2012,   33(2): 592-603. （SCI,   IF8.3）

[19] Jing Hu, Cuixia Chen, Shengzhong Zhang,   Xichen Zhao, Hai Xu, Xiubo Zhao, Jian R. Lu, Designed antimicrobial and   antitumor peptides with high selectivity, Biomacromolecules,   2011, 12(11): 3839-3843. （SCI, IF5.8,co-first author）

2.Patent

(1) An   amphiphilic self-assembled ultra-short peptide nanohemostatic material,   Patent Number: ZL 201510590566.9, Grant Announcement Date: May 4, 2016,   Invitor (design) : Chen Cuixia, Xu Hai, Zhang Yu, Bai Jingkun, Wang Jingxin,   Lu Jianren

(2) A novel   antimicrobial peptide, Application Number: 201310328915.0, Patent Number:   ZL201310328915.0, Chen Cuixia, Xu Hai, Lu Jianren, Hu Jing, Authorization   Announcement Date: January 13, 2016.

(3) Chen   Cuixia, Xu Hai, Wang Jingxin, Zhang Yu, Bai Jingkun, A novel hydrogel for   cell adhesion and its preparation method, Chinese Journal of Chemical Engineering,   2016, 26 (1) : 79-81

(4)   Preparation and application of fecL3-mediated intelligent polypeptide   hydrogel, Application Number: 201510830551.5, Chen Cuixia, Xu Hai, Bai   Jingkun, Zhang Yu, Wang Jingxin, Patent Date: 14 October 2016  

(5)   Preparation of hydrogel polypeptide, Application Number: CN201610166119.5,   Chen Cui-xia, Xu Hai, Zhang Yu.  Patent Grant Date: October 2019    

(6)   Preparation of polypeptide hydrogel and its hydrogel preparation, Application   Number: CN201610165810.1, Chen Cui-xia, Xu Hai, Zhang Yu.  Date of   patent grant: February 2019  

(7) A novel   polypeptide with anti-tumor activity, Application No. :   CN201710196075.5  Patent Grant Date: November 2020  

◎Awards and Honors

[1] Second   Prize of the Second Teaching Innovation Competition for Teachers.  (1/4)   

[2] Second   Prize of Science and Technology Progress of Jilin Province, (3/8)

◎Courses Offered

Undergraduate：《Biochemistry》《Molecular Biology》

Postgraduate：《Gene Engineer》《Applied Molecular Biology》

◎Student Training

1.Supervise Postgraduate Students

Assisted and supervised 6 doctoral   students, 6 academic students and 10 professional master students. I have   supervised 20 graduated students, among which 5 work in universities and 15   work in biological enterprise.

2.Typical student：

3.Admissions Instructions：