Zhiqing Zhang(Professor)

  Name：

Zhiqing   Zhang

Academic Title：

Professor

Advisor Type：

Doctoral Supervisor

  Department：

  Department of Chemistry

Research Interests：

Colloid and Interface Chemistry

  E-Mail：

zhangzq@upc.edu.cn

  Telephone：

Lab:A713

◎Educational Background

1996-2000, Bachelor of Science, School   of Chemistry, Shandong University

2000-2005, PhD , Key Laboratory of   Colloid and Interface Chemistry, Ministry of Education, Shandong   University 

2011-2011, Beijing Foreign Studies   University, Advanced English class for Overseas Study sponsored by the   Ministry of Education

2012-2013, Visiting scholar, University   of California, USA

2018-2018, Fudan University, China   University of Petroleum (East China) special training class for middle-level   cadres 

◎Work Experience

2005-2007，School of Chemistry and Molecular   Engineering, East China University of Science and Technology, lecturer

2007-， School of Chemistry and Chemical Engineering, China   University of Petroleum (East China), Professor, Vice President.

◎Research Direction

[1] Self-assembly and targeted diagnosis   and treatment of biological macromolecules; Construction of DNA biomolecular   assembly; DNA nanorobot; Nucleic acid molecular beacon; DNA rolling circle   amplification; Targeted detection and treatment of cancer; Gene editing and   gene therapy

[2] Colloid and interface chemistry;   Synthesis, properties and application of new surfactants, amphiphilic   polymers and other fine chemicals

[3] Oil field chemicals: Including crude   oil demulsifier, pour point depressant, viscosity depressant, sewage   treatment agent, corrosion inhibitor and scale inhibitor, asphalt dispersant,   new fracturing fluid of oil and gas, etc.

◎Research Project

Our research group has undertaken more   than 20 research projects.

◎Representative Papers and Patents

Published more than 120 papers, applied and   authorized for 10 patents and edited 3 monographs

1. Paper

[1] Zhiqing Zhang*, Nana Liu, Zichen   Zhang, Dongyan Xu, Shuai Ma, Xiufeng Wang, Ting Zhou, Guodong Zhang and Fang   Wang*. Construction of aptamer-based molecular beacons with varied blocked   structures and targeted detection of thrombin, Langmuir, 2021, 37(29):   8738-8745..

[2] Hong Wang, Ting Zhou*, Wenjing Li,   Zhen Wang, Yanbing Liu, Fang Wang, Xiufeng Wang, Guodong Zhang, Zhiqing   Zhang*. Oligonucleotides-templated gold nanoclusters as a label-free   fluorescent probe: Ferrous Ions and glucose detection based on Fenton   reaction and mechanistic investigation, Colloids and Surfaces A: Physicochem.   Eng. Aspects, 2021, 628: 127229.

[3] Zhiqing Zhang*, Jie Ma, Guodong   Zhang,* Xiaoyan Ding, Ruyan Zhang, Ting Zhou, Xiufeng Wang, Fang Wang.   Large-scale DNA nanoarrays with controllable fluorescence switch constructed   by RCA simplified origami. Langmuir, 2020, 36 (37): 10989-10995.

[4] Zhiqing Zhang*, Shanshan Wang, Jie   Ma, Ting Zhou*, Fang Wang, Xiufeng Wang, Guodong Zhang. Rolling Circle   Amplification-Based Polyvalent Molecular Beacon Probe Assisted   Signal-Amplification Strategies for Sensitive-Detection of B16 Cells. ACS   Biomaterials Science & Engineering, 2020, 6(5): 3114-3121.

[5] Ting Zhou, Chenqi Zhang, Hong Wang,   Xuefeng Kang, Zhiqing Zhang*, Fang Wang, Xiufeng Wang, Guodong Zhang.   Comparison Investigation on the Adsorption Affinity of DNA Molecules to the   Gold Surface Based on the Kinetic and Thermodynamic Analysis of 4Nitrophenol   Reduction, Journal of Physical Chemistry C, 2020, 124: 4595-4604.

[6] Fang Wang, Zhiqing Zhang*, Ying Wei,   Ting Zhou, Xiufeng Wang, Guodong Zhang. Rheology study of wormlike micellar   solution formed by 1-hexadecyl-3-methylimidazolium tetrafluoroborate ionic   liquids in present of sodium salicylate. Journal of Dispersion Science and   Technology, 2020, online.

[7] Zhiqing Zhang*, Shanshan Wang,   Zichen Zhang, Jie Ma, Xiufeng Wang*, Ting Zhou, Fang Wang, Guodong Zhang,   Rolling Circle Amplification-based Polyvalent Molecular Beacon Probe for   Signal-amplifying and Sensitive-Detection of Thrombin, Chemical Journal of   Chinese Universities, 2019, 40(12): 2465-2470.

[8] Zhiqing Zhang, Tingting Liu,   Shanshan Wang, Jie Ma, Ting Zhou, Fang Wang, Xiufeng Wang, Guodong Zhang,   DNA-Templated Gold Nanocluster as a Novel Fluorometric Sensor for Glutathione   Determination, Journal of Photochemistry and Photobiology A: Chemistry, 2019,   370: 89-93.

[9] Zhiqing Zhang*, Tingting Liu,   Changle Yue, Shanshan Wang, Jie Ma, Ting Zhou*, Fang Wang, Xiufeng Wang,   Guodong Zhang, Label-free and Ultrasensitive Fluorescence Assay for Fe3+   Detection using DNA-Templated Ag Nanoclusters, Colloids and Surfaces A:   Physicochem. Eng. Aspects, 2019, 579: 123656.

[10] Ting Zhou, Jing Yuan, Zhiqing   Zhang, Xia Xin, Guiying Xu*,  The   comparison of imidazolium Gemini surfactant [C14-4-C14im]Br2 and its   corresponding monomer as corrosion inhibitors for A3 carbon steel in   hydrochloric acid solutions: Experimental and quantum chemical studies,   Colloids and Surfaces A: Physicochem. Eng. Aspects, 2019, 575: 57-65.

[11] Chunhuan Shi, Zhiqing Zhang, Fang   Wang, Yuxia Luan. Active-targeting docetaxel-loaded mixed micelles for   enhancing antitumor efficacy, Journal of Molecular Liquids, 2018, 264:   172-178.

[12] Ting Zhou, Tingting Liu , Zhiqing   Zhang,* Guodong Zhang, Fang Wang, Xiufeng Wang, Shu zhen Liu, Hongzhi Zhang,   Shanshan Wang, Jie Ma. Investigation on catalytic properties of au nanorods   with different aspect ratios by kinetic and thermodynamic analysis, Journal   of Solid State Chemistry, 2018, 263: 11-17.     

[13] Zhiqing Zhang, Hongzhi Zhang, Fang   Wang*, Guodong Zhang, Ting Zhou, Xiufeng Wang, Shuzhen Liu, Tingting Liu, DNA   Block Macromolecules Based on Rolling Circle Amplification Act as Scaffolds   to Build Large-scale Origami Nanostructures, Macromolecular Rapid   Communications, 2018, 39(15): 1800263.

[14] Zhiqing Zhang, Shuzhen Liu, Ting   Zhou*, Hongzhi Zhang, Fang Wang, Guodong Zhang, Xiufeng Wang, Tingting Liu,   Salt-induced Assembly Transformation of DNA-AuNPs Conju-gates Based on RCA   Origami: From Linear Arrays to Nanorings, Langmuir 2018, 34: 8904-8909.

[15] Zhiqing Zhang, Fang Wang, Huihui   Nie, Ting Zhou, Guodong Zhang, Xiufeng Wang, Mei Cui & Yunze Li. A simple   strategy for the synthesis of Zn-IL-SBA-15 by sol–gel and the   application in desulfurization, Journal of Sol-Gel Science and Technology,   2017, 82(3): 827-833.

[16] Zhiqing Zhang, Mei Cui, Fang Wang,   Ting Zhou, Guodong Zhang & Xiufeng Wang. Synthesis, characterization, and   adsorptive desulfurization behavior of Merrifield resin supported polymeric   ionic liquids with different alkyl chain lengths, Colloid Polym Sci,2017, 295   (10): 1863–1871.

[17] Ting Zhou, Zhiqing Zhang*, Xuemei   Zhang, Chen Wang, Guiying Xu and Yanlian Yang. Self-assembled Chiral   Nanostructures of Amphiphilic Peptide: From Single Molecule to Aggregate,   Journal of Peptide Science, 2017, 23: 803-809.

[18] Shuzhen Liu, Zhiqing Zhang*, Fang   Wang, Ting Zhou, Xiufeng Wang, Guodong Zhang, Tingting Liu, Hongzhi Zhang,   Study on the Synthesis of DNA via Rolling Circle Amplification,Acta   Physico-Chimica Sinica, 2017, 33(10): 2052-2057.

[19] Hongzhi Zhang, Zhiqing Zhang*, Fang   Wang, Ting Zhou, Xiufeng Wang, Guodong Zhang, Tingting Liu, Shuzhen Liu,   Application of Structural DNA Nanotechnology,Acta Physico-Chimica Sinica,   2017,33(8):1520-1532.  

[20] Chunhuan Shi, Zhiqing Zhang, Fang   Wang, Xiaoqing Ji, Zhongxi Zhao, Yuxia Luan. Docetaxel-loaded PEO–PPO–PCL/TPGS mixed micelles for overcoming multidrug resistance and   enhancing antitumor efficacy. Journal of Materials Chemistry B, J. Mater.   Chem. B, 2015, 3(20), 4259-4271.

[21] Chunhuan Shi, Zhiqing Zhang,   Jiaxing Shi, Fang Wang, Yuxia Luan. Co-delivery of docetaxel and chloroquine   via PEO–PPO–PCL/TPGS micelles for overcoming multidrug   resistance.International Journal of Pharmaceutics, 2015, 495(2): 932–939.

[22] Fang Wang, Zhiqing Zhang*, Tao Wang,   Yunze Li, Mei Cui. Synthesis, Characterization, and Demulsification Behavior   of Amphiphilic Dendritic Block Copolymers, Journal of Dispersion Science and   Technology, 2015, 36(8): 1097-1105.

[23] Zhiqing Zhang, Mark A. Eckert, M.   Monsur Ali, Linan Liu, Dong-ku Kang, Elizabeth Chang, Leonard S. Sender,   David A. Fruman, Weian Zhao. DNA-Scaffolded Multivalent Ligands to Modulate   Cell Function, Chembiochem, 2014, 15(9): 1268-1273.封面文章.

[24] Zhiqing Zhang, M. Monsur Ali, Mark   A. Eckert, Dong-ku Kang, Yih Yang Chen, Leonard S. Sender, David A. Fruman,   Weian Zhao. A polyvalent aptamer system for targeted drug delivery,   Biomaterials, 2013, 34(37), 9728-9735.

[25] M. Monsur Ali, Feng Li, Zhiqing   Zhang, Kaixiang Zhang, Dong-ku Kang, J. Ankrum, C. Le, Weian Zhao. Rolling   circle amplification: A versatile tool for chemical biology, materials   science and medicine, Chem. Soc. Rev., 2014, 43(10), 3324-3341.

[26] Chengcheng Ren, Fang Wang*, Zhiqing   Zhang, Huihui Nie, Nan Li, Mei Cui. Synthesis, surface activity and aggregation   behavior of Geminiimidazolium surfactants 1,3-bis(3-alkylimidazolium-1-yl)   propanebromide, Colloids and Surfaces A: Physicochem. Eng. Aspects, 2015,   467: 1–8.

[27]Shan Yang, Zhiqing Zhang*, Fang   Wang, Lijuan Feng, Xiaoxia Jiang, Chuntian Yang, Xianhong Jiang, and Guoqiang   Liu. The synthesis and the bulk rheological properties of the highly-branched   block polyethers, Polymer Science Series A, 2014, 56(6), 917-927.

[28] Lijuan Feng, Zhiqing Zhang*, Fang   Wang, Tao Wang, Shan Yang. Synthesis and Evaluation of Alkyl Acrylate-Vinyl   Acetat-Maleic Anhydride Terpolymers as Cold Flow Improvers for Diesel Fuel,   Fuel Processing Technology, 2014, 118, 42-48.

[29] Lanxia Zhao, Jing Liu, Longlong   Zhang, Ya Gao, Zhiqing Zhang, Yuxia Luan. Self-assembly properties,   aggregation behavior and prospective application for sustained drug delivery   of a drug-participating catanionic system, International Journal of   Pharmaceutics, 2013, 452(1-2), 108-115.

[30] Yan Lin, Fang Wang, Zhiqing Zhang,   Jie Yang, Ying Wei. Polymer-supported ionic liquids: synthesis,   characterization and application in fuel desulfurization, Fuel, 2014, 116,   273-280.  2014-1-1

[31] Ying Wei, Fang Wang, Zhiqing Zhang,   Chengcheng Ren, Yan Lin. Micellization and Thermodynamic Study of   1-Alkyl-3-methylimidazolium Tetrafluoroborate Ionic Liquids in Aqueous   Solution, J. Chem. Eng. Data, 2014, 59 (4), 1120–1129.

[32] Nan Li, Fang Wang,* Zhiqing Zhang,   Huihui Nie, Chengcheng Ren, and Mei Cui. Synthesis and Desulfurization   Performance of Functional Silica Gel Modified by Polymeric 1‑Vinyl-3-ethylimidazolium   Tetrafluoroborate Ionic Liquids, Ind. Eng. Chem. Res. 2014, 53(43), 16664−16671.

[33] Lifang Xu, Zhiqing Zhang*, Fang   Wang, Dongdong Xie, Shan Yang, Tao Wang, Lijuan Feng, Chengchai Chu.   Synthesis, characterization, and self-assembly of linear poly(ethylene   oxide)-block–poly(propylene   oxide)-block–poly(e-caprolactone) (PEO–PPO–PCL) copolymers. J. Colloid and   Interface Sci. Journal of Colloid and Interface Science2013, 393, 174-181.

[34] Fang Wang, Zhiqing Zhang*, Jie   Yang, Liping Wang, Yan Lin, Ying Wei. Immobilization of room temperature   ionic liquid (RTIL) on silica gel for adsorption removal of thiophenic sulfur   compounds from fuel. Fuel, 2013, 107, 394–399.

[35] Shan Yang, Zhiqing Zhang*, Fang   Wang, Lijuan Feng, Tao Wang. Surface Properties and Aggregation Behaviors of   Amphiphilic Hyperbranched Block Polyethers in Aqueous Solution, Journal of   Polymer Research, 2013, 20(8), 205.

[36] Shan Yang, Zhiqing Zhang*, Fang   Wang, Xiaoxia Jiang, Chunming Liu, Xixi Liang. Cosolvent Effect on the   Aggregation of Amphipathic Highly-Branched Diblock Polyether in Aqueous   Solution, Journal of Polymer Research, 2013, 20, 307.

[37] Zhiqing Zhang, F. Wang, D. Li, J.   Yang. Interfacial Composition, Thermodynamic Properties and Structural   parameters of [bmim][BF4]+Cetyltrimethylammonium Bromide+Alkanol+Toluene   Microemulsion, Journal of Dispersion Science and Technology, 2012, 33,   141-146.

[38] Fang Wang, Zhiqing Zhang*, Dong Li,   Jie Yang, Chengchai Chu, Lifang Xu. Dilution Method Study on the Interfacial   Composition, Thermodynamic Properties and Structural Parameters of   [bmim][BF4]+Brij-35+1-butanol+Toluene Microemulsion,J. Chem. Eng. Data, 2011,   56 (8):  3328–3335.

[39] Zhiqing Zhang, Fang Wang.   Aggregation behavior of polyether block copolymers with dendritic structure   in aqueous solutions. Journal of Dispersion Science and Technology 2008, 29,   1092-1097.

[40] Zhiqing Zhang, Jin Mu. Hydrothermal   synthesis of ZnO nano-bundles controlled by PEO-PPO-PEO block copolymers. J.   Colloid and Interface Sci. 2007, 307, 79-82.

[41] Zhiqing Zhang, Jin Mu. Hydrothermal   synthesis of γ-MnOOH   nanowires and α-MnO2 dendritic clusters in different   oxidation systems. Solid State Communications 2007, 141, 427-430.

[42] Zhiqing Zhang, Jin Mu. Effect of   hydrothermal time, pH and alkali on crystal phase and morphology of manganese   oxides. Journal of Dispersion Science and Technology 2007, 28(5), 793-796.

[43] Zhiqing Zhang, Jin Mu. Fabrication   of ZnO nanorods in colloidal systems formed by PEO‐PPO‐PEO block copolymers. Journal of Dispersion Science and Technology   2006, 27, 769-772.

[44] Zhiqing Zhang, Guiying Xu, Fang   Wang, Shuli Dong, Yijian Chen. The demulsification by amphiphilic dendrimer   copolymers. J. Colloid and Interface Sci., 2005, 282, 1-4.

[45] Zhiqing Zhang, Guiying Xu, Fang   Wang, and Guangqing Du. Aggregation behaviors and interfacial properties of   oxyethylated nonionic surfactants. Journal of Dispersion Science and   Technology 2005, 26(3), 297-302.

[46] Zhiqing Zhang, Guiying Xu, Fang   Wang, Shuli Dong, Yimin Li. Characterization and Demulsification of   Poly(ethylene oxide)-block-Poly (propylene oxide)- block-Poly(ethylene oxide)   Copolymers. J. Colloid and Interface Sci. 2004, 277, 464-470.

[47] Xia Xin, Guiying Xu, Yajing Wang,   Hongzhi Mao, Zhiqing Zhang. Interaction between star-like block copolymer and   sodium oleate in aqueous solutions. European Polymer Journal, 2008, 44,   3246-3255.

[48] Xia Xin, Guiying Xu, Taotao Zhao,   Yanyan Zhu, Xiaofeng Shi, Houjian Gong, Zhiqing Zhang. Dispersing Carbon   Nanotubes in Aquous Solutions by a Starlike Block Copolymer. Journal of   Physical Chemistry C, 2008, 112, 16377-16384.

[49] Jin Mu, Zhenfang Gu, Lei Wang,   Zhiqing Zhang, Hua Sun, Shi-Zhao Kang. Phase and shape controlling of MnS   nanocrystals in the solvothermal process. Journal of Nanoparticle Research   2008, 10, 197-201.

[50] Fang Wang, Bo Fang, Zhiqing Zhang,   Saiyu Zhang, Yandong Chen. The effect of alkanol chain on the interfacial   composition and thermodynamic properties of diesel oil microemulsion. Fuel,   2008, 87(12), 2517.

[51] Fang Wang, Bo Fang, Zhiqing Zhang,   Saiyu Zhang. Mechanism of electrical percolation of w/o microemulsions formed   by nonionic surfactants. Journal of Dispersion Science and Technology, 2008,   29(8), 1166-1172.

[52] Fang Wang, Bo Fang, Zhiqing Zhang,   Lijie Qiao, Yandong Chen. Dilution method study on the interfacial   composition, thermodynamic properties and structural parameters of HCl   /cetyltrimethylammonium chlorine /alkanol/ diesel oil microemulsion: Effect   of HCl in water pool. Journal of Chemical and Engineering data, 2008, 53(6),   1256-1261.

[53] Xia Xin, Guiying Xu, Zhiqing Zhang,   Yijian Chen and Fang Wang. Aggregation behavior of star-like PEO–PPO–PEO block copolymer in aqueous solution. European Polymer Journal,   2007, 43(7), 3106-3111.

[54] Lingyun Liu, Zhiqing Zhang,   Shi-Zhao Kang and Jin Mu. Effect of SnO2 nanocrystals on the emission of Eu3+   ions in silica matrix. Journal of Dispersion Science and Technology 2007,   28(5), 769-772.

[55] Fang Wang, Guiying Xu, Zhiqing   Zhang, Xia Xin. Synthesis of monodisperse CdS nano-spheres in inverse   microemulsion system formed by dendritic polyether copolymer. Eur. J. Inorg.   Chem. 2006, 1, 109.

[56] Fang Wang, Guiying Xu, Zhiqing   Zhang, Shue Song, Shuli Dong. A systematic morphosynthesis of barium sulfate   in the presence of phosphonate inhibitor. J. Colloid and Interface Sci. 2006,   293, 394.

[57] Jin Mu, Zhenfang Gu, Zhiqing Zhang,   Xiangqing Li, Shi-Zhao Kang, Lei Wang. Effect of hydrothermal on the   crystalline phase and morphology of manganese oxide nanocrystals. Journal of   Dispersion Science and Technology 2006, 27, 1223.

[58] Zhenfang Gu, Hua Sun, Jin Mu,   Zhiqing Zhang, Lei Wang, Shi-Zhao Kang. Hydrothermal synthesis and   characterization of Cd1-xMnxS (0≤x<1) nanocrystals. Journal of Dispersion Science   and Technology 2006, 27, 1187.

[59] Fang Wang, Guiying Xu, Zhiqing   Zhang. The effect of pH on morphological control of barium hydrogen phosphate   crystal by a double-hydrophilic copolymer. Materials Letter2005,59(7) , 808.

[60] Fang Wang, Guiying Xu, Zhiqing   Zhang. Morphology control of barium sulfate by PEO-PPO-PEO as crystal growth   modifier. Colloids and Surfaces A 2005,259, 165.

[61] Gui-Ying Xu, Ai-Min Chen, Zhi-Qing   Zhang, Shu-Li Dong, Li-Qiang Zheng, Ye-Bang Tan. Aggregation behaviors of   amphiphilic copolymers with methylacrylic acid segments at interface.   Colloids and surfaces A 2005, 257-258, 503.

[62] Xiaorong Cao, Guiying Xu, Yinming   Li, Zhiqing Zhang. Aggregation of poly(ethylene oxide)-poly(propylene oxide)   block copolymers in aqueous solution: DPD simulation study. J. Phys. Chem. A   2005, 109, 10418.

[63] Yiming Li, Guiying Xu, Yuxia Luan,   Shiling Yuan, Zhiqing Zhang. Studies on the interaction between tetradecyl   dimethyl betaine and sodium carboxymethyl cellulose by DPD simulations.   Colloids and Surfaces A 2005, 257-258, 385.

[64] Qiang Shen, Hao Wei, Liancheng   Wang, Yong Zhou, Ying Zhao, Zhiqing Zhang, Dujin Wang, Guiying Xu, Duanfu Xu.   Crystallization and aggregation behaviors of calcium carbonate in the   presence of poly(vinylpyrrolidone) and sodium dodecyl sulfate. Journal of   Physical Chemistry B, 2005, 109(39), 18342-18347.

[65] Li Xiao, Guiying Xu, Zhiqing Zhang,   Youbao Wang, Ganzuo Li. Adsorption of Sodium Oleate at the Interface of Oil   Sand/Aqueous Solution. Colloids and surfaces A2003, 224, 199-206.

[66] Yuxia Luan, Guiying Xu, Shiling   Yuan, Li Xiao, Zhiqing Zhang. Comparative Studies of Structurally Similar   Surfactants: Sodium Bis (2-ethylhexyl) Phosphate and Sodium Bis   (2-ethylhexyl) Sulfosuccinate. Langmuir 2002, 18, 8700.

[67] Yuxia Luan, Guiying Xu, Shiling   Yuan, Li Xiao, Zhiqing Zhang. Investigations on NaDEHP and AOT: Computer   Simulation and Surface Tension Measurements.    Colloids and surfaces A 2002, 210, 61.

2.Patent

ZL201710041384.5, ZL201710052068.8,   ZL201010134853.6, ZL200310105425, ZL2021114750130, et al.

◎Representative Works

[1] Physical Chemistry

[2] Colloids and Interface Science

[3] Proceedings of the 16th Colloidal   and Interface Chemistry Conference of the Chinese Chemical Society

◎Awards and Honors

I have won more than 30 awards including   patent excellence award in petroleum and chemical industry in China.

◎Courses Offered

Undergraduate：《Physical Chemistry》《Colloids and Interface Science》《Experiments   in Physical Chemistry》

Postgraduate：《Colloids and   Interface Science》

◎Student Training

I have supervised more than 30 doctoral   and master students, and more than 40 undergraduate students.

◎Part-time Academic Job

[1] Member of Shandong Chemical And Chemical   Society

[2] Editorial Board of Colloids and Polymers

[3] Member of Shandong Physical Chemistry   Committee

[4] Member of Chinese Chemical Society

[5] Member of Nano-oncology Professional   Committee of Chinese Anti-Cancer Association

[6] Dissertation review expert of Academic   Degree Center of Ministry of Education

[7] Guest reviewer of ACS Nano,   Biomaterials, Soft Matter, Macromolecules, Fuel, Analytical Chemistry,   Biomacromolecules, Journal of Molecular Liquids, Journal of Colloid and   Interface Science