Zhihua Peng(Associate Professor)

  Name：

Zhihua Peng

Academic Title：

Associate Professor

Advisor Type：

Master's Supervisor

  Department：

Department of Chemistry

Research Interests：

Organometallic Chemistry

  E-Mail：

zpech@upc.edu.cn

  Telephone：

18353268464

◎Educational Background

1996.9-2000.7，Department of Chemistry, Qufu Normal   University，B.S.

2000.9-2003.7，Department of Chemistry, East China   Normal University，M. S.

2008.1-2011.8，Ludwig-Maximilians-Universität München   (LMU)，Ph.D.

◎Work Experience

2003.7-2006.3，Shanghai institute of Organic   Chemistry，Research   Assistant

2006.1-2007.1，Unilever China R & D Center，Research Assistant

2007.3-2007.11，WuXi AppTec，Associate Research Fellow

2011.10-2020.11，Department of   Chemistry, College of Science, China University of Petroleum (East China)，Lecturer

2020.12-2021.12，Department of   Chemistry, College of Science, China University of Petroleum (East China)，Associate Professor

2022.1-present, Department of Chemistry, College of Chemistry and Chemical Engineering,   China University of Petroleum (East China)，Associate Professor

◎Research Direction

For   much of modern history, the use of simple chemical units has served as the   primary platform from which to build molecular complexity. While   modifications of these feedstock chemicals have enabled incredible progress   in the pharmaceutical, agrochemical, and materials industries, the process   itself is often non-trivial. To this end, transition metal catalysis has   become an indispensable tool in the development of efficient and   synthetically viable strategies for activation of these molecules. However,   the continued use of non-earth abundant, toxic and expensive metal   catalysts represents an enormous challenge that must be addressed if true   sustainability in these industries is to be realized. To this end, our   research group focuses on the invention and implementation of basic catalytic   alternatives, which secure sustainable and environmentally friendly   approaches in organic chemistry.

The research   in the Peng lab focuses on the development of new sustainably catalytic   reactions, with deep insight into the inherent mechanism, and their   applications in the fields of pharmaceuticals and material science,   including:

[1] The   preparation and reactions of new organometallic reagents.

[2]   Bismuth-mediated redox reactions.

[3] 3d-Metal catalyzed   reactions.

◎Research Project

[1]Shandong   Provincial Natural Science Foundation (ZR2019MB045)

[2]Fundamental Research Funds for the Central Universities (17CX02069)

[3]National Natural Science Foundation of China (21202205)

[4]China Postdoctoral Science Foundation Funded Project (2013T60688 and   2012M521382)

[5]   Shandong Provincial Natural Science Foundation   (ZR2012BQ006)

[6]   Fundamental Research Funds   for the Central Universities (15CX02059A)

◎Representative Papers and Patents

1. Paper

[1] Direct C-H Arylation and Alkylation of   Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

    Zhihua Peng,* Chuanman Yu, Yilei Wang,   Dongyue Wei, and Cuiyu Jiang

Organometallics2021, 40, 3678–3688.

[2] N-Alkylation of Amines with   Alcohols Catalyzed by Manganese(II) Chloride or   Bromopentacarbonylmanganese(I)

    Dongyue Wei, Peng Yang, Chuanman Yu, Fengkai Zhao,   Yilei Wang, and Zhihua Peng*

    J. Org. Chem. 2021, 86,   2254−2263.

[3] Direct and Efficient C(sp³)‐H Bond   Alkylation of Tetrahydroisoquinolines and Isochroman with Alkylzinc Reagents

Zhihua Peng*, Yilei Wang, Zhi Yu, Hao Wu, Shanshan Fu, Linhua Song, Cuiyu Jiang

Adv. Synth. Catal.2019, 361, 2048–2053 (VIP).

[4]  Direct Arylation of Benzyl Ethers with Organozinc   Reagents

Zhihua   Peng*, Yilei Wang, Zhi Yu, Dezhi Zhao, Linhua Song, and Cuiyu Jiang

J. Org. Chem.2018, 83,   7900–7906.

[5]  Catalytic Regioselective C–H Acetoxylation of Arenes   Using 4,6-Dimethoxy-1,3,5-Triazin-2-Yloxy as a Removable/Modifiable Directing   Group

Zhihua   Peng*, Zhi Yu, Tian Li, Na Li, Yilei Wang, Linhua Song, Cuiyu Jiang

Organometallics2017, 36,   2826–2831.

[6] Efficient C(Sp³)–H   Bond Arylation of Tetrahydroisoquinolines with Knochel-Type Arylzinc Reagents   under Oxidative Conditions

Zhihua Peng*, Zhi Yu, Dong-Huang Chen, Shuyuan Liang, Liwei   Zhang, Dezhi Zhao, Linhua Song, Cuiyu Jiang

Synlett2017, 28,   1835–1839.

[7] Highly Diastereoselective   Preparation of Aldol Products Using New Functionalized Allylic Aluminum   Reagents

Zhi-Liang Shen, Zhihua   Peng, Chun-Ming Yang, Julian Helberg, Peter Mayer, Ilan Marek, and Paul   Knochel*

Org. Lett.2014, 16, 956-959.

[8] The   Transition-Metal-Catalyst-Free Oxidative Homocoupling of Organomanganese   Reagents Prepared by the Insertion of Magnesium into Organic Halides in the   Presence of MnCl₂·2LiCl

Zhihua Peng,* Na Li, Xinyang Sun, Fang   Wang, Lanjian Xu, Cuiyu Jiang, Linhua Song, and Zi-Feng Yan

Org. Biomol. Chem.2014, 12,   7800–7809.

[9] Preparation of 2-Magnesiated 1,3,5-Triazines via an Iodine-Magnesium   Exchange

Zhihua Peng, Benjamin A. Haag, and Paul Knochel*

Org. Lett. 2010, 12, 5398-5401

[10] Diastereoselective   Synthesis of Homoallylic Alcohols with Adjacent Tertiary and Quaternary   Centers by Using Functionalized Allylic Aluminum Reagents

    Zhihua Peng, Tobias D. Blümke, Peter Mayer, and Paul   Knochel*

Angew. Chem. Int. Ed.2010,49, 8516 –8519.

[11] Preparation   of Functionalized Organomanganese(II) Reagents by Direct Insertion of   Manganese to Aromatic and Benzylic Halides

    Zhihua Peng, and Paul Knochel*

Org. Lett. 2011, 13, 3198-3201.

[12] Preparation   of Polyfunctional Indazoles and Heteroarylazo Compounds Using Highly   Functionalized Zinc Reagents

    Benjamin Haag, Zhihua Peng,   and Paul Knochel*

Org. Lett.2009, 11, 4270-4273.

[13] Preparation of   functionalized organoaluminiums by direct insertion of aluminium to   unsaturated halides

    Tobias Blümke, Yi-Hung Chen, Zhihua   Peng and Paul Knochel*

Nature Chemistry, 2010, 2, 313-318.

[14] Palladium-Catalyzed   Functionalization of Indoles with 2-Acetoxymethyl-Substituted   Electron-Deficient Alkenes

    T Shengming Ma*, Shichao Yu, Zhihua   Peng, and Hao Guo

J. Org. Chem., 2006,71, 9865-9868.

◎Representative Works

◎Awards and Honors

◎Courses Offered

Undergraduate：《Organic Synthesis》《Spectral Analysis》《Special English for Chemistry》

Postgraduate：《Advanced Analytical   Chemistry》

◎Student Training

1.Supervise Postgraduate Students

Supervised Independently 3   academic postgraduates and assisted in supervising 3 academic postgraduates

2.Admissions Instructions：

Recruiting academic   postgraduates majoring in chemistry

◎Part-time Academic Job